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          新万博体育
          2019年4月26日

          模拟显示的发动如何释放从细胞膜囊泡

          由乔斯林·达菲

          乔斯林·达菲
          • 科学梅隆大学
          • 412-268-9982

          A computer simulation developed by 生物物理学家 at 新万博体育 has determined how the protein dynamin works with the cell membrane to bring important molecules into the cell. Their findings, published in 网上生活, can be used to better study the role the process plays in dynamin-related diseases like Charcot-Marie-Tooth disease and other neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Alzheimer's, Parkinson's and Huntington's diseases.


          卡内基·梅隆 生物物理学家 have developed a computer simulation that shows how dynamin works with the cell membrane to bring molecules into the cell.

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          “dynamin上的结构是非常公知的,”卡内基梅隆说 物理 教授 马库斯deserno, who led the study. "And yet, its actual mode of operation has been ardently debated ever since it was first discovered more than two decades ago."


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          卡内基·梅隆 生物物理学家, including Deserno, have created some of the most effective computer simulations of a lipid membrane. These allow researchers to see, often for the first time, what happens at the cell membrane under predetermined conditions.

          Their simulation showed that twirling was the most efficient method for membrane fission, while elongation actually reduced efficiency. Furthermore, the twirling process showed changes in the dynamin molecules that resembled those seen in previous experiments. 

          "Our findings offer a detailed biophysical assessment of how dynamin's geometry, elasticity, molecular interactions and expenditure of chemical energy work together to drive membrane fission — or how this might fail in several dynamin-related diseases," Deserno said.

          In addition to using the model to study disease, Deserno hopes that the model's concept can be transferred to other membrane remodeling enzymes that are poorly understood, like the ESCRT-III complex, which plays a role in neurological disorders and the transmission of viruses between cells.

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